Components Of Most Influential Components - 992 Words

We identified the affected components of most influential components in both type of perturbations. We combined all the four environmental conditions to construct the network of the most influential components with downstream targets. On these networks we mapped druggable proteins and cancer associated genes. Under inactivating perturbations, we obtained the network of PI3K, EGFR, PP2A, GRK and CaM (Figure 7A). Under activating perturbations, we obtained the network of influential components i.e. EGFR, IL1_TNFR, ERK, SHP2, RKIP, Ras, Gbg_i, Fak, Integrins, and PP2A (Figure 7B). The ranking of these components based on number of affected components is shown in Table 4. We observed that the EGFR is affecting most number of components under activating as well as inactivating perturbations. Interestingly, EGFR is a validated drug target for cancer [34]. The other influential components such as PI3K, ERK, and Ras have been previously explored in multiple cancer types. However, the influential components consist of the most important drug candidates that block cell proliferation in cancer cells. Some of these components have been associated with the drug resistance. For example, in non-small cell lung cancer, EGFR showed mutation in its kinase domain, Epithelial–mesenchymal transition, and mechanisms to develop resistance to gefitinib [35]. In colorectal, and head and neck cancers KRAS mutation, EGFR-S492R mutation, and increased ErBb signaling are responsible for resistanceShow MoreRelated Roger’s Theory as compared to that of Ellis’ Theory Essay973 Words   |  4 PagesAnderson (n.d) states, â€Å"Carl Rogers, a pioneering psychotherapist and the most influential psychologist in American history was one of the most prominent people of his time.† Rogers’ ideas and practices brought about a change in the school of humanistic psychology. What he learned in philosophy and philosophy of education influenced his personal life experiences which led him to a revolutionary of theory of therapy (Corsini, 2011 p. 148). According to an electrical resource, Client –centered therapyRead MoreGeneral and Task Environment954 Words   |  4 Pagesgeneral environment or the task environment? Why is it important for a manager to make a clear assessment of these environments? The general environment and task environment are the two components that make up an organisations external environment. The external environment of an organisation includes influential elements that both directly and indirectly shape and impact its future, and as of late, has developed into an area of increasing importance to managers worldwide. However, how do managersRead MoreCognitive Psychology Essay1069 Words   |  5 Pagesroots of psychology. 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Cognition has aspects involved in mental processes that includeRead MoreAre You Focused On Your Small Business Branding?. Any Business1064 Words   |  5 Pagesconsumers and expected customers get from your business. An influential brand communicates about the products and services your company provides and develops trust and reliability at the same time. Your brand exists in day to day interaction with your customers and the picture your share, post you update on your we solution, the content of your marketing resources along with the social media post. In addition, your brand is all about the components that creates a brand that includes logo, packaging, coloursRead MoreFactors To Affecting The Gas Assisted Gravity Drainage Process?841 Words   |  4 Pagesto determine the most influential geological parameters affecting the Gas Assisted Gravity Drainage process, sensitivity analysis was conducted through Design of experiments (DoE). DoE combines multi-level of each parameter to create many computer experiments evaluated by the compositional reservoir simulation. The factors that were adopted in this case are horizontal permeability, anisotropy ratio $K_{v}/K_{h}$, and porosity, all given for the entire reservoir. The most influential factors are diagnosedRead MoreOverview of Four Seasons Strategy1411 Words   |  6 Pageswe succeed .† The Four Seasons main purpose is to provide the finest luxury accommodations to their guests. The company’s goal is to be regarded as the best in hotel and resort management. The Four Seasons believes their employees are their most vital assets. The quality of the employees is paramount for the company in their achievement of organizational objectives. Four Seasons believes it takes a unified and cooperative employee effort to satisfy the guests’ needs and to achieveRead MoreLet1 Task 11087 Words   |  5 PagesVictor Vroom in 1964. It will first explain the three key components and relationships of the expectancy theory of motivation. These components include Expectancy, Instrumentality and Valence. In addition, it will explain how to enhance the motivation of employees in a fictional but real-life modeled scenario using the Expectancy theory of motivation. After studying this paper, the reader should be able to explain the main components of the Expectancy theory of motivation and apply it’s conceptsRead MoreCoca Cola Great Britain ( Ccgb ) Essay930 Words   |  4 Pagesout of 13 locations (Odell, 2015). CCGB currently produce 19 brands and 96 different products, UK sales rates of 4 billion bottles and cans per year. Which has aided in CCGB achieve as the market leaders and cemented their presence as one of the most globally recognisable products. (Jorgensen, 1994). In 2015 Coca Cola unveiled a new retail marketing strategy, entitled â€Å"the One Brand† strategy, designed to directly addressing the issue of changing consumer attitudes and behaviours, caused by theRead MoreThe Code Of Ethics For Educators Standards775 Words   |  4 Pagesprofession. The three components from the two codes of ethics we had for this class that I consider most important are Georgia Code of Ethics for Educators Standard 4: Honesty, Georgia Code of Ethics for Educators Standard: 10 Professional Conduct, and CEC Special Education Standards for Professional, Ethical Principles, Standard J – â€Å"advocating for professional conditions and resources that will improve learning outcomes of individual with exceptionalities.† The first component I selected, honesty

The Nsa s National Security Agency - 2363 Words

The National Security Agency’s (NSA) warrantless collection of metadata has been questioned on constitutional grounds. Specifically, the NSA’s program has been argued to be in violation of the Fourth Amendment of the Constitution, which states that all citizens are to be free from any unreasonable search or seizure. Proponents of the NSA’s collection of metadata believe that it is a crucial tool in preventing terrorist attacks, while opponents of the program believe that its questionable constitutional validity, along with its lack of clear success in preventing a single terrorist attack, leaves the NSA’s metadata collection program in desperate need of reform or outright abolishment. I. THE NSA’S PURPOSE AND THE EVOLUTION OF GOVERNMENT SURVEILLANCE It is important to note what the NSA is tasked to do before discussing the constitutional arguments against its metadata program. As Abdulmajeed Alhogbani, in his work, â€Å"Going Dark: Scratching the Surface of Government Surveillance,† informs, the agency has two tasks: â€Å"1) information assurance, which prevents foreign agents from obtaining classified information, and 2) signals intelligence, which collects and analyzes foreign intelligence† (475). Metadata collection does not fall under either of these tasks. Prior to the establishment of the National Security Agency in 1952, the earliest surveillance measure enacted in the United States was the Communications Act of 1934, which centralized â€Å"the regulatory process ofShow MoreRelatedThe Nsa Spying Is A Major Issue1077 Words   |  5 Pagesrequested when we walk into a dentist office or doctor’s office, the local liquor store, or when we are using social media sites like Instagram, Facebook, and Google. This is all collected, stored, and tracked by the NSA, and what is our government is doing with it is unknown. In today’s world NSA spying is a major issue and should be noticed by the people of the U.S. The US government, with assistance from major carriers including ATT, has engaged in massive, illegal dragnet surveillance of the domesticRead MoreNsa Should Be Stopped. Nsa1177 Words   |  5 Pages NSA should be stopped The NSA, The National Security Agency that is under the government control was initially intended to protect the USA by tethering through technology devices to attempt to pick up any suspicious activities. The problem is that many feel as if the NSA has no right to evade their privacy. The NSA should be penalize every time they do so, or should have some type of warrant, but only for last resort, or stopped completely. There are many other ways to go about finding troublesomeRead MoreAmerican Peoples Privacy Is Being Spied on by the NSA and It Is Wrong703 Words   |  3 Pagesviolated by the NSA. Everyday person today in the USA uses technology to communicate and pleasure use: e-mail, texting, social networks, calling, blogs, forums, instant messaging, Internet and using search engines. The American people personal computer or electronic information is spied on and collect by the NSA this is wrong this is violating the fourth amendment. Who is spying and collecting personal electronic information from American people by the National Security Agency known as NSA. They areRead MoreU.s. National Security Agency1242 Words   |  5 Pageslives of its citizens including, the protagonist, Winston. Even though our society is not as invasive we have our own big brother, the NSA. Although it protects U.S. national security, the government should discontinue the surveillance done by the NSA because it is detrimental the U.S. economy the Constitution and the citizens of the U.S. The National Security Agency, NSA, is an intelligence organization of the United States government, responsible for global monitoring, collection and processing ofRead MorePresident Reagan Signed Into Law A National Security Decision Directive1344 Words   |  6 PagesOn September 17th, 1984 President Reagan signed into law a national security decision directive, NSDD-145, titled â€Å"National Policy on Telecommunications and Automated Information System Security†. Even at that time, the government officials understood that computers were susceptible to interception, unauthorized electronic access, and related form of technical espionage and exploitation. It was noted, that hostile agencies were â€Å"extensively† hacking into computers, and that terrorist groups and criminalRead MoreGovernment Surveillance Of The United States975 Words   |  4 PagesOver the past few years, government surveillance in the United States has become a widely debated issue with two comp letely different sides. The National Security Agency, a government agency known for it’s efforts in spying and surveillance, has been at the center of this issue since it’s founding in the 1950’s. The Cold War had just begun and the United States government was doing anything they could to find potential terrorists and communists. In fact, many famous people including Einstein wereRead MoreSetting The Stage For The Events That Took Place1487 Words   |  6 Pagesâ€Å"biggest leak of government secrets in history† (Breslow, 2014, para. 2), Edward Snowden, a former National Security Agency (NSA) contractor, contacted Glenn Greenwald of the worldwide new source, The Guardian, in December 2012 stating, ‘I’ve got some stuff you might be interested in’ (Breslow, 2012, para. 1-2). The events that took place after the initial contact would send the United States, government agencies, media outlets, and digital experts racing for answers reg arding legalities, what informationRead MoreDomestic Surveillance During The United States1474 Words   |  6 PagesDomestic Surveillance in the Unites States has been going on for decades without the public s knowledge. Domestic Surveillance didn t seem important in the eye of the American government. After the September attacks (9/11) congress started to treat Domestic Surveillance as a number one priority. After September 11th Congress passed a law to use military force for those responsible for the attacks in New York, NY. The go ahead with using military force did not give the President to use surveillanceRead MoreAnti Transportation Security Agency ( Tsa )1393 Words   |  6 Pageslives one fateful September morning, we realized we left the doors to our country wide open to attack. As a result, we ramped up our security and instituted new programs to combat terrorism to make ourselves invulnerable to similar attacks. But as the government began to develop programs within the National Security Agency (NSA) and the Transportation Security Agency (TSA) to prevent such an attack from ever happening again, the government began to infringe on the rights which were laid down in theRead MoreNational Security Agency Is Unconstitutional887 Words   |  4 PagesThe NSA is an unconstitutional Federal government agency established by a failed president. In 1952, the worst president in U.S. History, President Truman, established the National Security Agency (NSA). Truman is known for committing the worst crime against humanity by using a nuclear bomb on the people of Hiroshima and Nagasaki in Japan, as well as for losing China and North Korea. For a president that is known for his poor performance on foreign policy, Truman establishes the NSA to safeguard

Operations Management Service Management Operations

Question: Discuss about the Operations Management of Service Management Operations. Answer: Introduction Forecasting is considered to be one of the major tools for decision making, which is made by properly analysing the past data and thereby making a proper estimation about the future. In this assignment, the three types of time horizons relating to forecasting are being discussed along with different types of methods which can be used readily in each kind of time range. Classification of time horizon: Forecasting is classified under three types of times horizons which are as follows: Principles Short range Medium range Long range Duration 1 month 3 months 3 months - 3 years Type of decisions Tactical Strategic and tactical Strategic Effect Random fluctuations Seasonal fluctuations Long term business cycles Range of uncertainty Low Considerable High Examples Revision of production plans and job scheduling Planning, production, sales and budgeting. Introduction of New Products , Change in location and New development in business Table: Three types of times horizons Source: (Fitzsimmons and Fitzsimmon 2013) Short term (1 month 3 months). Under this type of time horizon, the span of time varies ranges from few days to few weeks. Trends, seasonality and the different cycles tend to have little effect on such time range. The decisions taken are mostly tactical, with a low degree of uncertainty .The nature of data is mostly in quantitative basis where the Random Fluctuations are considered to be a major element effecting the short time phase. e.g.: work assignments and scheduling of jobs. Medium Range (3 months 3 years). Under medium range of time horizon, the span of time ranges from 3 months to 3 years approximately. Under this stage, the decisions regarding productions, proper planning, sales and budgeting are being taken. These decisions taken are mostly considered as a combination of both strategic and tactical where significant degrees of uncertainty exist. Long range forecasting ( 3 years). Long term in forecasting refers to the range of time which is greater than 1 year. Under this, the decisions taken are fully in a strategic manner, with a high degree of uncertainty. According to Fitzsimmons and Fitzsimmon (2013), the major focus area under long range forecasting is introduction of new products, development of new business and decisions regarding the locality. Types of forecasting methods which can be used in each of the time horizons: There are two types of forecasting methods namely Quantitative and qualitative, which can explained as follows taking into account the three time horizons of forecasting. Quantitative methods can of methods using the past information they are: Trend analysis: This kind of method is mostly used in short term forecasting, where the past and the historical data are being examined for future exploration. The various models which are used in this context are regression, exponential smoothing etc (Hyndman and Athanasopoulos 2014). Qualitative methods: are usually used in the medium and the long run which can be discussed as follows: Market Research: This kind of method is used in the medium range of forecasting, where research is being carried out in a systematic manner. Under this method, the market researchers tend to collect all the relevant information in relation to demographic, personal and economic information. Depending on the research work, important decisions regarding planning, budgeting and sales and production are being taken. Delphi technique: According to Hyndman and Athanasopoulos (2014), Delphi technique also known as expert opinion refers to a range of panel experts who are being interrogated by means of a set of questionnaires. After such interrogation the responses provided by the experts are being used again for further questioning, this is mainly done in order to remove the effect of bandwagon and helps to get an accurate estimation about the future. Another method which is used in estimating long range time horizon is sales force survey opinion. It is also known as the collective method, where the opinions of the sales person are being taken into account rather than the consumers. Conclusion: In can be concluded that forecasting is the method of making future predictions based on the analysis of the past and present trends. Under this assignment, the three major time horizon namely short range forecast, middle range forecast and long range forecast are being discussed keeping in mind the amount of risk and uncertainty attached to each . Taking this time horizon factor in account there are two types of methods which can be best suited for each of the time series which are quantitative methods and qualitative methods, where the former deals with short term forecast and the latter predicts about the medium and long term time series. Reference: Fitzsimmons, J. and Fitzsimmons, M., 2013.Service management: Operations, strategy, information technology. McGraw-Hill Higher Education. Hyndman, R.J. and Athanasopoulos, G., 2014.Forecasting: principles and practice. OTexts

Black Experience Essay Research Paper WEB DuBois free essay sample

Black Experience Essay, Research Paper W.E.B DuBois criticized Washington greatly because of his political and educational doctrines. DuBois was an advocator of higher instruction and gifted black leaders. He felt that Washington s advocation for industrial larning finally hindered the black person and placed them in a place to accept a position of a 2nd category citizen. DuBois felt that inkinesss should endeavor for their rights and non put them aside for economic addition. Due to increasing battle to get the better of racial barriers, Washington s thoughts began to free influence by the 1910. DuBois along with Marcus Garvey brought in new, more extremist thoughts. Despite the fact that Garvey and Dubois presented more extremist thoughts than those of Washington, they were still political antagonists. DuBois believed that one could work within the model of American society to make alteration. Garvey believed that inkinesss could neer obtain justness in a state where the bulk of the population was white. We will write a custom essay sample on Black Experience Essay Research Paper WEB DuBois or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page He advocated that inkinesss should see Africa as their fatherland and they should settle at that place. Garvey founded his Back-to-Africa, upon this doctrine. Washington, DuBois, and Garvey have extremely different point of views, but his can be attributed to the fact that they came from really different backgrounds. Booker T. Washington was born a slave in Virginia. After emancipation he worked in what would be considered comparatively unskilled labour places. He subsequently went on to analyze at Hampton University where he would subsequently learn. The experiences in his life fused with his experience with instruction would take him to establish Tuskegee Institute in Alabama. In Washington s life he found that difficult industrial work and basic instruction assisted in his success. He used his ain life experiences as the greatest theoretical account for his thoughts on the black race. DuBois had a really contrasting background to that of Washington. DuBois came from a more privileged background. His life work centered around the betterment of African Americans, but he wanted to make so with the concerted attempt of inkinesss every bit good as broad white. DuBois attracted largely upper category and rational inkinesss in the beginning of his calling. He subsequently shifted his idea to appeal to everyone through emotion. Despite his attempts in the ulterior part of his calling to appeal to everyone, DuBois tended to estrange poorer inkinesss, who turned to Marcus Garvey s school of idea. Garvey grew up in impoverished Jamaica where he received minimum schooling. He relocated to Latin America and so E ngland where he was exposed to the Pan-African Movement. These thoughts were the foundation for his Back to Africa motion in the United States. The thought of a dissentious African American community did non merely manifest itself in the opposing sentiments of Washington, DuBois and Garvey. It surfaced in the motions and leaders that were the replacement of these three work forces. Martin L. King represented different ideals than those of Malcolm X. Malcolm X had really different position points than those of the likes of Eldridge Cleaver, Stokley Carmichael and Huey Newton. Basically these other three opposing position points stem from a different clip period, but the same type of splits in the schools of thought arise. These leaders basically represented and appealed to different groups of black people. The black community has neer obtained a triumph for all the sectors of its community. Yes, the civil rights motion made great headrooms for the black community politically, but it did non win at turn toing the economic conditions of the hapless black individual. It besides did non appeal to the black person who was concerne d about advancing the complete political and economic control of the black community. The civil rights motion was chiefly a triumph that has led to the prosperity of the in-between category inkinesss of the 1960 s. In the interim groups like the black under category have been left to drop or swim in America s capitalistic economic system which thrives of the really fact that there is an lower class. Washington s, DuBois and Garvey s point of views are clearly representative of positions that can be taken on by modern-day Afro-american in the new millenary. There is no cosmopolitan black American experience, the exclusive consolidative commonalty possibly that all inkinesss to some degree experience the effects of bondage. Soon in the United States the black community can be divided in to many subdivisions such as upper category, in-between category, working category, under category. With in all of these classs, there are farther divisions of the Afro-american that has recent West-Indian, African, Latin and European roots. All of these subsets of the black community have wholly different life positions. The black jobs of the 1920 s remain unreciprocated and the continue to resurface continually in the millenary. Black America must recognize that it is merely through he corporate digest of different schemes like those of Washington, DuBois and Garvey can black America present the blow that will be necessary to truly undertake the jobs of most of black America.

Analysis of Human Resource System at Riordan

Analysis of Human Resource System at Riordan Free Online Research Papers Riordan Manufacturing is a plastics manufacturing company with operations in the United States and in China. Riordan employs around 500 employees. Currently, the tracking of employees is done on different systems throughout the company. The tracking system is severely in need of automation and consolidation of employee information. To retain employee satisfaction and stay competitive with other companies, it is necessary for Riordan to update or implement a new system to be more effective. Right now the company’s human resources department does not meet these needs. The company’s HRIS system was installed in 1992. It is a part of the financial systems package and keeps track of the following employee information: Personal information (such as name, address, marital status, birth date, etc.) Pay rate Personal exemptions for tax purposes Hire date Seniority date (which is sometimes different than the hire date) Organizational information (department for budget purposes, manager’s name, etc.) Vacation hours (for non-exempt employees) Changes to this information are submitted in writing by the employee’s manager and are entered into the system by the payroll clerk. Training and development records are kept in an Excel worksheet by the training and development specialist. Each recruiter maintains applicant information for open positions. Rà ©sumà ©s are filed in a central storage area, and an Excel spreadsheet is used to track the status of applicants. Workers’ compensation is managed by a third-party provider, which keeps its own records. Employee files are kept by individual managers; there is no central employee file area. Managers are also responsible for tracking FMLA absences and any requests for accommodation under the ADA. The compensation manager keeps an Excel spreadsheet with the results of job analyses, salary surveys and individual compensation decisions. Employee relations specialists track information about complaints, grievances, harassment complaints, etc. in locked files in t heir offices (Riordan Human Resources, 2004). The scope of this project is either to handle all the above HR activities with a single, commercially-available application, develop an application that can handle those activities competently, or outsource the responsibilities. Whichever solution is chosen, the system requirements and functional requirements must also be met. After reviewing the annual employee satisfaction survey results job satisfaction has decreased significantly. Employees were also asked about the working conditions and I found from the survey the average for this was the employee agreed. Next, employees were asked about personal opportunity for transfer, promotions, job training and other opportunities at Riordan. This is another area where the employees score has gone down significantly. In the Cooperation area of the survey it questions the employees overall how they relate to other employees they work with. This has overall remained the same. Compensation and Benefits section of the survey has shown the most significant decline over the years. Employees are feeling they are underpaid for the work they do and would leave the company if a job opportunity arose paying 10% more they would leave Riordan. Employees are also feeling if they do a good job and work hard they will be reward fairly is not true. Communication in the company has basically remain the same, employees are overall agree with questions they were asked. Management satisfaction at Riordan has slightly decrease over the three years and over the last quarter complaints regarding unfair discipline and inadequate training are becoming increasingly high (Riordan Manufacturing, 2003/2004). As Yvonne McMillan stated in a memo to Dale Edgel, where she has put together a summary of employee grievances, they are seeing an increasing amount of complaints directly contributing to the employee satisfaction issues. Ms. McMillan also states supervisor training is needed as many of the issues seem to be directly related to supervisory misconduct (Yvonne McMillan, personal communication, May 1, 2004). Research Papers on Analysis of Human Resource System at RiordanMoral and Ethical Issues in Hiring New EmployeesRiordan Manufacturing Production PlanThe Project Managment Office SystemAnalysis of Ebay Expanding into AsiaResearch Process Part OneOpen Architechture a white paperTwilight of the UAWNever Been Kicked Out of a Place This NiceBionic Assembly System: A New Concept of SelfIncorporating Risk and Uncertainty Factor in Capital

Cloud-based BPM Model Essay Example | Topics and Well Written Essays - 2000 words

Cloud-based BPM Model - Essay Example The organization of these activities alongside human/system factors through a systematic workflow, enable a business to gain not only an extraordinary visibility but the entire control over their daily operation (Dumas,LaRosa,Mendling and Reijers, 2013).It can be used by employees to troubleshoot anomalies in business orders or determine missing items as well. The BPM mainly revolves around the cycling processes and begins at the model phase that provides the basic approach to continuous improvement of the business processes. All aspects of the BPM are implemented in their respective phase in relation to detailed activities involved in each phase. The first cycle begins with capturing the processes in model phase that entails the purpose for analyzing current business processes. The analysis in the model results to improved version of the business process, further design, implementation and evaluation. BPM emerged not only as a management principle tool but also as a suite of softwar e solutions to overcome the deficiencies in traditional business process applications. Although the BPM has been established to be very successful, serious obstacles persist in its enterprise-scale implementation. Variable such as startup costs, resource availability and technical limitation cannot be undermined. Premises are the responsible for the installation of their own BPM. This is a challenge to business premises since the upfront outlay cost requires a lot of capital. Installation of the BPM.

History, Consuption of BLUE JEANS (FASHION in U.S History) assignment Research Paper

History, Consuption of BLUE JEANS (FASHION in U.S History) assignment - Research Paper Example It looked dark blue as it was generally colored with indigo, a type of colorant derived from plants in India and America. Almost 20 million tons of indigo is produced for the dyeing of jeans every year, though each pair of jeans requires only a few grams of the dye. It was worn by workers as the fabric was very durable and strong. Gold was found in California in the year 1848 which gave rise to the popular Gold rush, the workers of the gold mine required long lasting cloths that would last long and not be worn off easily. A man called Leob Strauss who lived in New York shifted to San Francisco which is quite close to California and started a wholesale business of supplying clothes, later he changed his name to Levi from Leob, who the founder of the well known Levis Jeans Company. The major problem faced by the miners was that the pockets of their jeans would easily tear away from the jeans, so a person called Jacob Davis thought of an idea to overcome this problem. He had the idea of using metal fasteners to prevent the pockets from tearing away and to hold the pockets and the jeans together. Davis wanted to copyright his idea but due to lack of funds. He could not do so. In the year 1872 Davis sent a written proposal to Strauss, offering him a deal if Strauss agreed to pay fort the copyright, the proposal was accepted by Strauss and Davis started manufacturing copper fasteners. Levi attached a leather label on their jeans in the year 1886; it displayed two horses pulling a pair of jeans from in opposite directions, this was to display and advertise the strength of the jeans, and represented that even if it is pulled by two horses it would not tear apart. Hollywood stared making many western movies in 1930’s, where cowboys generally wore denim waist overalls; jeans were called that back then. This denim waist overall that